Download e-book for kindle: An Experimental Study of Pituitary Tumours: Genesis, by Hong Giok Kwa

By Hong Giok Kwa

ISBN-10: 3540027149

ISBN-13: 9783540027140

ISBN-10: 3642855660

ISBN-13: 9783642855665

"Let the states of equilibrium and concord exist in perfection and a cheerful order will be successful via heaven and earth and all issues should be nourrished and flourish. " (MENCIUS, in "The Doctrine of the Mean." ) of their common surroundings some of the crops and animals that experience inhabited a quarter for a long time have chanced on a usual stability. The inhabitants of crops and animals of this sort of area looks to control itself automobile matically; the variety of each one species is saved inside quite strict limits by way of a usual stability of forces. The creation of a brand new aspect in such an equilibrated state of affairs may end up in a "disaster" whilst the stability of forces that acted as an ideal self-steering machine up until the advent of that new point, fails to maintain the variety of that point less than regulate. a widely known instance for this sort of (man's) "interference with nature's stability of forces" is the importation of rabbits in Australia. simply because Australia's fauna didn't comprise any of the rabbit's "natural enemies" a "rabbit inhabitants explosion" this unsatisfied choice. An equilibrated scenario can develop into disturbed otherwise. An instance of one other kind of (man's) "interference with nature's stability of forces" is the creation of recent know-how and medication in up until eventually lately "backward" international locations. the consequent bring up in to be had nutrition and the higher hygienic criteria got rid of the older tests on inhabitants raise resembling famine and peri-natal dying.

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Rumen etc. were provided twice weekly. b) Method of administration of the drugs used. For these experiments the natural oestrogen oestrone has been used. This was dissolved in drinking water for the experiments with mice (BOOT and MUHLBocK, 1956). A dose of 125 f-lg of oestrone per litre of drinking water is just sufficient to cause constant vaginal oestrus in ovariectomized mice and the oestrone dose reaching the general circulation presumably corresponds with the average oestrogen production in intact females, or is somewhat below it.

The results of classifying the pituitaries of rats of various treatment groups and of untreated rats are given in Table 6. Compared with most other strains reported (see II. I. ), rats of the R-Amsterdam strain have a relatively low incidence of spontaneous pituitary tumours. The incidence obviously increases with age and amongst animals from the breeder colony that are kept to a very old age of more than 1000 days, the incidence has risen to over 60%. Since the duration of treatment is considered more relevant to the pituitary tumour incidence than the actual age of the rats and most experimental animals were at the age of 2 to 3 months at the start of the experiments, 75 days have 3* 36 The incidence and the rate of growth of experimental pituitary tumours been deducted from the actual age of the control rats so as to allocate them to the various periods of "duration of treatment".

The growth curves of pituitary tumours in male Cs7BI mice (5 and 6); in orchidectomized male (C s7 Bl x DBAr) Fl mice (7 and 8) and in female (C s7Bl x DBAr) F1 mice (9 and 10) induced by oestrone and by "radiothyroidectomy" respectively are represented. Statistical evaluation by 44 The incidence and the rate of growth of experimental pituitary tumours analysis of covariance! showed that there are no indications whatsoever to conclude that the oestrone growth curve and the "radiothyroid- zoo . ~ ..

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An Experimental Study of Pituitary Tumours: Genesis, Cytology and Hormone Content by Hong Giok Kwa


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